A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4(+) T cells

The transcription factor ThPOK promotes CD4(+) T cell differentiation in the thymus. Here, using a mouse strain that allows post-thymic gene deletion, we show that ThPOK maintains CD4(+) T lineage integrity and couples effector differentiation to environmental cues after antigenic stimulation. ThPOK...

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Pubblicato in:Nat Immunol
Autori principali: Vacchio, Melanie S., Wang, Lie, Bouladoux, Nicolas, Carpenter, Andrea C., Xiong, Yumei, Williams, Linus C., Wohlfert, Elizabeth, Song, Ki-Duk, Belkaid, Yasmine, Love, Paul E., Bosselut, Rémy
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4251968/
https://ncbi.nlm.nih.gov/pubmed/25129370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2960
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