ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis

We used a genome-wide screen in N-ethyl-N-nitrosourea (ENU)-mutagenized mice to identify genes in which recessive loss-of-function mutations protect against pathological neuroinflammation. We identified an R367Q mutation in the ZBTB7B (ThPOK) protein in which homozygosity causes protection against e...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Kennedy, James M., Georges, Anna, Bassenden, Angelia V., Vidal, Silvia M., Berghuis, Albert M., Taniuchi, Ichiro, Majewski, Jacek, Lathrop, Mark, Behr, Marcel A., Langlais, David, Gros, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6977123/
https://ncbi.nlm.nih.gov/pubmed/31792077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00845-19
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