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DNA sequence selectivity of human topoisomerase I-mediated DNA cleavage induced by camptothecin
In probing the mechanism of inhibition of hypoxia inducible factor (HIF-1) by campothecins, we investigated the ability of human topoisomerase I to bind and cleave HIF-1 response element (HRE), which contains the known camptothecin-mediated topoisomerase I cleavage site 5′-TG. We observed that the s...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley Subscription Services, Inc., A Wiley Company
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2774443/ https://ncbi.nlm.nih.gov/pubmed/19472416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.138 |
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