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Degrons in protein substrates program the speed and operating efficiency of the AAA+ Lon proteolytic machine
AAA+ proteases are ATP-fueled machines that bind protein substrates via a degradation tag, unfold the molecule if necessary, and then translocate the polypeptide into a chamber for proteolysis. Tag recognition is normally viewed as a passive reaction. By contrast, for the AAA+ Lon protease, we show...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2774003/ https://ncbi.nlm.nih.gov/pubmed/19841274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910392106 |
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