Matrix Metalloproteinase-14 Mediates a Phenotypic Shift in the Airways to Increase Mucin Production

Rationale: Induced mainly by cigarette smoking, chronic obstructive pulmonary disease (COPD) is a global public health problem characterized by progressive difficulty in breathing and increased mucin production. Previously, we reported that acrolein levels found in COPD sputum could activate matrix...

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Main Authors: Deshmukh, Hitesh S., McLachlan, Anne, Atkinson, Jeffrey J., Hardie, William D., Korfhagen, Thomas R., Dietsch, Maggie, Liu, Yang, Di, Peter Y. P., Wesselkamper, Scott C., Borchers, Michael T., Leikauf, George D.
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2009
Teme:
B. Chronic Obstructive Pulmonary Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773913/
https://ncbi.nlm.nih.gov/pubmed/19661247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200903-0328OC
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