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Ku70 regulates Bax-mediated pathogenesis in laminin-α2-deficient human muscle cells and mouse models of congenital muscular dystrophy
The severely debilitating disease Congenital Muscular Dystrophy Type 1A (MDC1A) is caused by mutations in the gene encoding laminin-α2. Bax-mediated muscle cell death is a significant contributor to the severe neuromuscular pathology seen in the Lama2-null mouse model of MDC1A. To extend our underst...
Gorde:
| Egile Nagusiak: | , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Oxford University Press
2009
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2773263/ https://ncbi.nlm.nih.gov/pubmed/19692349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp399 |
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