Structural Perturbations Induced by the α-Anomer of the Aflatoxin B(1) Formamidopyrimidine Adduct in Duplex and Single-Strand DNA

[Image: see text] The guanine N7 adduct of aflatoxin B(1)exo-8,9-epoxide hydrolyzes to form the formamidopyrimidine (AFB-FAPY) adduct, which interconverts between α and β anomers. The β anomer is highly mutagenic in Escherichia coli, producing G → T transversions; it thermally stabilizes the DNA dup...

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Detalhes bibliográficos
Main Authors: Brown, Kyle L., Voehler, Markus W., Magee, Shane M., Harris, Constance M., Harris, Thomas M., Stone, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2009
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773149/
https://ncbi.nlm.nih.gov/pubmed/19831353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja902052v
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