Unraveling the Aflatoxin–FAPY Conundrum: Structural Basis for Differential Replicative Processing of Isomeric Forms of the Formamidopyrimidine-Type DNA Adduct of Aflatoxin B(1)

Aflatoxin B(1) (AFB) epoxide forms an unstable N7 guanine adduct in DNA. The adduct undergoes base-catalyzed ring opening to give a highly persistent formamidopyrimidine (FAPY) adduct which exists as a mixture of forms. Acid hydrolysis of the FAPY adduct gives the FAPY base which exists in two separ...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Brown, Kyle L., Deng, James Z., Iyer, Rajkumar S., Iyer, Lalitha G., Voehler, Markus W., Stone, Michael P., Harris, Constance M., Harris, Thomas M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693076/
https://ncbi.nlm.nih.gov/pubmed/17117870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja063781y
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky