Unraveling the Aflatoxin–FAPY Conundrum: Structural Basis for Differential Replicative Processing of Isomeric Forms of the Formamidopyrimidine-Type DNA Adduct of Aflatoxin B(1)

Aflatoxin B(1) (AFB) epoxide forms an unstable N7 guanine adduct in DNA. The adduct undergoes base-catalyzed ring opening to give a highly persistent formamidopyrimidine (FAPY) adduct which exists as a mixture of forms. Acid hydrolysis of the FAPY adduct gives the FAPY base which exists in two separ...

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Main Authors: Brown, Kyle L., Deng, James Z., Iyer, Rajkumar S., Iyer, Lalitha G., Voehler, Markus W., Stone, Michael P., Harris, Constance M., Harris, Thomas M.
Formato: Artigo
Idioma:Inglês
Publicado: 2006
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693076/
https://ncbi.nlm.nih.gov/pubmed/17117870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja063781y
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