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The aflatoxin B(1) formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma

A G to T mutation has been observed at the third position of codon 249 of the p53 tumor-suppressor gene in over 50% of the hepatocellular carcinoma cases associated with high exposure to aflatoxin B(1) (AFB(1)). Hypotheses have been put forth that AFB(1), in concert with hepatitis B virus (HBV), may...

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Detalhes bibliográficos
Main Authors: Smela, Maryann E., Hamm, Michelle L., Henderson, Paul T., Harris, Constance M., Harris, Thomas M., Essigmann, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC124458/
https://ncbi.nlm.nih.gov/pubmed/12011430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.102167699
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