The aflatoxin B(1) formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma

A G to T mutation has been observed at the third position of codon 249 of the p53 tumor-suppressor gene in over 50% of the hepatocellular carcinoma cases associated with high exposure to aflatoxin B(1) (AFB(1)). Hypotheses have been put forth that AFB(1), in concert with hepatitis B virus (HBV), may...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Smela, Maryann E., Hamm, Michelle L., Henderson, Paul T., Harris, Constance M., Harris, Thomas M., Essigmann, John M.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2002
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124458/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12011430/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.102167699
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