Amyloid β-Protein Dimers Isolated Directly from Alzheimer Brains Impair Synaptic Plasticity and Memory

Alzheimer’s disease (AD) constitutes a rising threat to public health. Despite extensive research in cellular and animal models, identifying the pathogenic agent present in the human brain and showing that it confers key features of AD have not been achieved. We extracted soluble amyloid β–protein (...

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書誌詳細
主要な著者: Shankar, Ganesh M., Li, Shaomin, Mehta, Tapan H., Garcia-Munoz, Amaya, Shepardson, Nina E., Smith, Imelda, Brett, Francesca M., Farrell, Michael A., Rowan, Michael J., Lemere, Cynthia A., Regan, Ciaran M., Walsh, Dominic M., Sabatini, Bernardo L., Selkoe, Dennis J.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772133/
https://ncbi.nlm.nih.gov/pubmed/18568035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1782
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