Amyloid β-Protein Dimers Isolated Directly from Alzheimer Brains Impair Synaptic Plasticity and Memory

Alzheimer’s disease (AD) constitutes a rising threat to public health. Despite extensive research in cellular and animal models, identifying the pathogenic agent present in the human brain and showing that it confers key features of AD have not been achieved. We extracted soluble amyloid β–protein (...

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Autors principals: Shankar, Ganesh M., Li, Shaomin, Mehta, Tapan H., Garcia-Munoz, Amaya, Shepardson, Nina E., Smith, Imelda, Brett, Francesca M., Farrell, Michael A., Rowan, Michael J., Lemere, Cynthia A., Regan, Ciaran M., Walsh, Dominic M., Sabatini, Bernardo L., Selkoe, Dennis J.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772133/
https://ncbi.nlm.nih.gov/pubmed/18568035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1782
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