Product Release Rather Than Chelation Determines Metal Specificity for Ferrochelatase

Ferrochelatase (protoheme ferrolyase, E.C. 4.99.1.1) is the terminal enzyme in heme biosynthesis and catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX (heme). Within the past two years x-ray crystallographic data obtained with human ferrochelatase have clearly shown...

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Main Authors: Medlock, Amy E., Carter, Michael, Dailey, Tamara A., Dailey, Harry A., Lanzilotta, William N.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771925/
https://ncbi.nlm.nih.gov/pubmed/19703464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.08.042
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