A π-Helix Switch Selective for Porphyrin Deprotonation and Product Release in Human Ferrochelatase

Ferrochelatase (protoheme ferrolyase, E.C. 4.99.1.1) is the terminal enzyme in heme biosynthesis and catalyzes the insertion of ferrous iron into protoporphyrin IX to form protoheme IX (heme). Due to the many critical roles of heme, synthesis of heme is required by the vast majority of organisms. De...

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Main Authors: Medlock, Amy E., Dailey, Tamara A., Ross, Teresa A., Dailey, Harry A., Lanzilotta, William N.
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2083577/
https://ncbi.nlm.nih.gov/pubmed/17884090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.08.040
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