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Structurally Simple Inhibitors of Lanosterol 14α-Demethylase Are Efficacious In a Rodent Model of Acute Chagas Disease

We report structure-activity studies of a large number of dialkyl imidazoles as inhibitors of Trypanosoma cruzi lanosterol-14α-demethylase (L14DM). The compounds have a simple structure compared to posaconazole, another L14DM inhibitor that is an anti-Chagas drug candidate. Several compounds display...

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Main Authors: Suryadevara, Praveen Kumar, Olepu, Srinivas, Lockman, Jeffrey W., Ohkanda, Junko, Karimi, Mandana, Verlinde, Christophe L. M. J., Kraus, James M., Schoepe, Jan, Van Voorhis, Wesley C., Hamilton, Andrew D., Buckner, Frederick S., Gelb, Michael H.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771698/
https://ncbi.nlm.nih.gov/pubmed/19463001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900030h
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