Rational Modification of a Candidate Cancer Drug for Use Against Chagas Disease

Chagas disease is one of the major neglected diseases of the world. Existing drug therapies are limited, ineffective and highly toxic. We describe a novel strategy of drug discovery of adapting an existing clinical compound with excellent pharmaceutical properties to target a pathogenic organism. Th...

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Hlavní autoři: Kraus, James M, Verlinde, Christophe LMJ, Karimi, Mandana, Lepesheva, Galina I., Gelb, Michael H, Buckner, Frederick S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715367/
https://ncbi.nlm.nih.gov/pubmed/19239254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801313t
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