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Rational Modification of a Candidate Cancer Drug for Use Against Chagas Disease
Chagas disease is one of the major neglected diseases of the world. Existing drug therapies are limited, ineffective and highly toxic. We describe a novel strategy of drug discovery of adapting an existing clinical compound with excellent pharmaceutical properties to target a pathogenic organism. Th...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2715367/ https://ncbi.nlm.nih.gov/pubmed/19239254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801313t |
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