Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

The relation of α-synuclein (αS) aggregation to Parkinson's disease (PD) has long been recognized, but the mechanism of toxicity, the pathogenic species and its molecular properties are yet to be identified. To obtain insight into the function different aggregated αS species have in neurotoxici...

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Main Authors: Karpinar, Damla Pinar, Balija, Madhu Babu Gajula, Kügler, Sebastian, Opazo, Felipe, Rezaei-Ghaleh, Nasrollah, Wender, Nora, Kim, Hai-Young, Taschenberger, Grit, Falkenburger, Björn H, Heise, Henrike, Kumar, Ashutosh, Riedel, Dietmar, Fichtner, Lars, Voigt, Aaron, Braus, Gerhard H, Giller, Karin, Becker, Stefan, Herzig, Alf, Baldus, Marc, Jäckle, Herbert, Eimer, Stefan, Schulz, Jörg B, Griesinger, Christian, Zweckstetter, Markus
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771093/
https://ncbi.nlm.nih.gov/pubmed/19745811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.257
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