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Interaction between Poly(ADP-ribose) and NuMA Contributes to Mitotic Spindle Pole Assembly

Poly(ADP-ribose) (pADPr), made by PARP-5a/tankyrase-1, localizes to the poles of mitotic spindles and is required for bipolar spindle assembly, but its molecular function in the spindle is poorly understood. To investigate this, we localized pADPr at spindle poles by immuno-EM. We then developed a c...

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Detalhes bibliográficos
Main Authors: Chang, Paul, Coughlin, Margaret, Mitchison, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770945/
https://ncbi.nlm.nih.gov/pubmed/19759176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-06-0477
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