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Interaction between Poly(ADP-ribose) and NuMA Contributes to Mitotic Spindle Pole Assembly

Poly(ADP-ribose) (pADPr), made by PARP-5a/tankyrase-1, localizes to the poles of mitotic spindles and is required for bipolar spindle assembly, but its molecular function in the spindle is poorly understood. To investigate this, we localized pADPr at spindle poles by immuno-EM. We then developed a c...

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Библиографические подробности
Главные авторы: Chang, Paul, Coughlin, Margaret, Mitchison, Timothy J.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Cell Biology 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770945/
https://ncbi.nlm.nih.gov/pubmed/19759176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-06-0477
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