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Mechanistic analysis of PCNA poly-ubiquitylation by the ubiquitin protein ligases Rad18 and Rad5

Poly-ubiquitylation is a common post-translational modification that can impart various functions to a target protein. Several distinct mechanisms have been reported for the assembly of poly-ubiquitin chains, involving either stepwise transfer of ubiquitin monomers or attachment of a preformed poly-...

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Autors principals: Parker, Joanne L, Ulrich, Helle D
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770100/
https://ncbi.nlm.nih.gov/pubmed/19851286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.303
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