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The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA
Mgs1, the budding yeast homolog of mammalian Werner helicase-interacting protein 1 (WRNIP1/WHIP), contributes to genome stability during undisturbed replication and in response to DNA damage. A ubiquitin-binding zinc finger (UBZ) domain directs human WRNIP1 to nuclear foci, but the functional signif...
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Auteurs principaux: | , , , |
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Format: | Artigo |
Langue: | Inglês |
Publié: |
Oxford University Press
2012
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Sujets: | |
Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3245944/ https://ncbi.nlm.nih.gov/pubmed/21911365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr738 |
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