The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA

Mgs1, the budding yeast homolog of mammalian Werner helicase-interacting protein 1 (WRNIP1/WHIP), contributes to genome stability during undisturbed replication and in response to DNA damage. A ubiquitin-binding zinc finger (UBZ) domain directs human WRNIP1 to nuclear foci, but the functional signif...

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Bibliografische gegevens
Hoofdauteurs: Saugar, Irene, Parker, Joanne L., Zhao, Shengkai, Ulrich, Helle D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2012
Onderwerpen:
Genome Integrity, Repair and Replication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245944/
https://ncbi.nlm.nih.gov/pubmed/21911365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr738
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