The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA

Mgs1, the budding yeast homolog of mammalian Werner helicase-interacting protein 1 (WRNIP1/WHIP), contributes to genome stability during undisturbed replication and in response to DNA damage. A ubiquitin-binding zinc finger (UBZ) domain directs human WRNIP1 to nuclear foci, but the functional signif...

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Bibliographic Details
Main Authors: Saugar, Irene, Parker, Joanne L., Zhao, Shengkai, Ulrich, Helle D.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245944/
https://ncbi.nlm.nih.gov/pubmed/21911365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr738
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