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The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI

Fanconi anemia (FA) is a rare genetic disorder characterized by bone marrow failure, congenital abnormalities, and an increased risk for cancer and leukemia. Components of the FA-BRCA pathway are thought to function in the repair of DNA interstrand cross-links. Central to this pathway is the monoubi...

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Detalhes bibliográficos
Main Authors: Williams, Stacy A., Longerich, Simonne, Sung, Patrick, Vaziri, Cyrus, Kupfer, Gary M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109534/
https://ncbi.nlm.nih.gov/pubmed/21355096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-311761
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