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Disruption of the Crossover Helix Impairs Dihydrofolate Reductase Activity in the Bifunctional Enzyme TS-DHFR from Cryptosporidium hominis

In contrast to most species, including humans, having monofunctional forms of the folate biosynthetic enzymes thymidylate synthase (TS) and dihydrofolate reductase (DHFR), several pathogenic protozoal parasites, including Cryptosporidium hominus, contain a bifunctional form of the enzymes on a singl...

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Detalhes bibliográficos
Main Authors: Vargo, Melissa A., Martucci, W. Edward, Anderson, Karen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769570/
https://ncbi.nlm.nih.gov/pubmed/18851711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20081247
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