Exploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein–protein interaction in C. hominis TS–DHFR

The bifunctional enzyme thymidylate synthase–dihydrofolate reductase (TS–DHFR) from the protozoal parasite Cryptosporidium hominis is a potential molecular target for the design of antiparasitic therapies for AIDS-related opportunistic infections. The enzyme exists as a homodimer with each monomer c...

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Detalhes bibliográficos
Main Authors: Martucci, W. Edward, Rodriguez, Johanna M., Vargo, Melissa A., Marr, Matthew, Hamilton, Andrew D., Anderson, Karen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855065/
https://ncbi.nlm.nih.gov/pubmed/24324854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3MD00141E
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