Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen

The essential enzyme thymidylate synthase-dihydrofolate reductase (TS-DHFR) is a validated drug target for many pathogens, but has been elusive in Cryptosporidium hominis, as active site inhibitors of the enzymes from related parasitic protozoa show decreased potency and lack of species specificity...

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Detalhes bibliográficos
Main Authors: Martucci, W. Edward, Udier-Blagovic, Marina, Atreya, Chloe, Babatunde, Oladapo, Vargo, Melissa A., Jorgensen, William L., Anderson, Karen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651159/
https://ncbi.nlm.nih.gov/pubmed/19059777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.11.054
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