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Disruption of the Crossover Helix Impairs Dihydrofolate Reductase Activity in the Bifunctional Enzyme TS-DHFR from Cryptosporidium hominis
In contrast to most species, including humans, having monofunctional forms of the folate biosynthetic enzymes thymidylate synthase (TS) and dihydrofolate reductase (DHFR), several pathogenic protozoal parasites, including Cryptosporidium hominus, contain a bifunctional form of the enzymes on a singl...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2769570/ https://ncbi.nlm.nih.gov/pubmed/18851711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20081247 |
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