Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

Activated protein C (APC) is a signaling protease with anticoagulant activity. Here, we have used mice expressing a mutation in superoxide dismutase-1 (SOD1) that is linked to amyotrophic lateral sclerosis (ALS) to show that administration of APC or APC analogs with reduced anticoagulant activity af...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Zhong, Zhihui, Ilieva, Hristelina, Hallagan, Lee, Bell, Robert, Singh, Itender, Paquette, Nicole, Thiyagarajan, Meenakshisundaram, Deane, Rashid, Fernandez, Jose A., Lane, Steven, Zlokovic, Anna B., Liu, Todd, Griffin, John H., Chow, Nienwen, Castellino, Francis J., Stojanovic, Konstantin, Cleveland, Don W., Zlokovic, Berislav V.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769191/
https://ncbi.nlm.nih.gov/pubmed/19841542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38476
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares