Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

Activated protein C (APC) is a signaling protease with anticoagulant activity. Here, we have used mice expressing a mutation in superoxide dismutase-1 (SOD1) that is linked to amyotrophic lateral sclerosis (ALS) to show that administration of APC or APC analogs with reduced anticoagulant activity af...

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Auteurs principaux: Zhong, Zhihui, Ilieva, Hristelina, Hallagan, Lee, Bell, Robert, Singh, Itender, Paquette, Nicole, Thiyagarajan, Meenakshisundaram, Deane, Rashid, Fernandez, Jose A., Lane, Steven, Zlokovic, Anna B., Liu, Todd, Griffin, John H., Chow, Nienwen, Castellino, Francis J., Stojanovic, Konstantin, Cleveland, Don W., Zlokovic, Berislav V.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2009
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769191/
https://ncbi.nlm.nih.gov/pubmed/19841542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38476
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