Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier

Activated protein C (APC), a serine-protease with anticoagulant, anti-inflammatory, and cytoprotective activities, is neuroprotective and holds potential to treat different neurological disorders. It is unknown whether APC crosses the blood-brain barrier (BBB) to reach its therapeutic targets in the...

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Bibliographische Detailangaben
Hauptverfasser: Deane, Rashid, LaRue, Barbra, Sagare, Abhay P., Castellino, Francis J., Zhong, Zhihui, Zlokovic, Berislav V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895315/
https://ncbi.nlm.nih.gov/pubmed/18841163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2008.117
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