Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity

The anticoagulant activated protein C (APC) protects neurons and endothelium via protease activated receptor (PAR)1, PAR3 and endothelial protein C receptor. APC is neuroprotective in stroke models. Bleeding complications may limit the pharmacologic utility of APC. Here, we compared the 3K3A-APC mut...

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Detalhes bibliográficos
Main Authors: Guo, Huang, Singh, Itender, Wang, Yaoming, Deane, Rashid, Barrett, Theresa, Fernández, José A., Chow, Nienwen, Griffin, John H., Zlokovic, Berislav V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692517/
https://ncbi.nlm.nih.gov/pubmed/19302148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2009.06664.x
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