Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity

Activated protein C (APC) is a protease with anticoagulant and cytoprotective activities. APC is neuroprotective in rodent models of stroke. But, an APC variant with reduced anticoagulant activity, 3K3A-APC, compared to wild type APC (wt-APC) shows greater neuroprotection with no risk for bleeding i...

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Hlavní autoři: Guo, Huang, Wang, Yaoming, Singh, Itender, Liu, Dong, Fernández, José A., Chow, Nienwen, Zlokovic, Berislav V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692505/
https://ncbi.nlm.nih.gov/pubmed/19166505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2009.05921.x
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