Suppression of K(ATP) channel activity protects murine pancreatic β cells against oxidative stress

The enhanced oxidative stress associated with type 2 diabetes mellitus contributes to disease pathogenesis. We previously identified plasma membrane–associated ATP-sensitive K(+) (K(ATP)) channels of pancreatic β cells as targets for oxidants. Here, we examined the effects of genetic and pharmacolog...

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Главные авторы: Gier, Belinda, Krippeit-Drews, Peter, Sheiko, Tatiana, Aguilar-Bryan, Lydia, Bryan, Joseph, Düfer, Martina, Drews, Gisela
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2009
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769178/
https://ncbi.nlm.nih.gov/pubmed/19805912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38817
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