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ATP binding without hydrolysis switches sulfonylurea receptor 1 (SUR1) to outward-facing conformations that activate K(ATP) channels
Neuroendocrine-type ATP-sensitive K(+) (K(ATP)) channels are metabolite sensors coupling membrane potential with metabolism, thereby linking insulin secretion to plasma glucose levels. They are octameric complexes, (SUR1/Kir6.2)(4), comprising sulfonylurea receptor 1 (SUR1 or ABCC8) and a K(+)-selec...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6416425/ https://ncbi.nlm.nih.gov/pubmed/30587573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005236 |
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