ATP binding without hydrolysis switches sulfonylurea receptor 1 (SUR1) to outward-facing conformations that activate K(ATP) channels

Neuroendocrine-type ATP-sensitive K(+) (K(ATP)) channels are metabolite sensors coupling membrane potential with metabolism, thereby linking insulin secretion to plasma glucose levels. They are octameric complexes, (SUR1/Kir6.2)(4), comprising sulfonylurea receptor 1 (SUR1 or ABCC8) and a K(+)-selec...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sikimic, Jelena, McMillen, Timothy S., Bleile, Cita, Dastvan, Frank, Quast, Ulrich, Krippeit-Drews, Peter, Drews, Gisela, Bryan, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416425/
https://ncbi.nlm.nih.gov/pubmed/30587573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005236
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