Methyl pyruvate stimulates pancreatic beta-cells by a direct effect on KATP channels, and not as a mitochondrial substrate.

In pancreatic beta-cells, methyl pyruvate is a potent secretagogue and is widely used to study stimulus-secretion coupling. In contrast with pyruvate, which barely stimulates insulin secretion, methyl pyruvate was suggested to act as an effective mitochondrial substrate. We show that methyl pyruvate...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Düfer, Martina, Krippeit-Drews, Peter, Buntinas, Linas, Siemen, Detlef, Drews, Gisela
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2002
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223048/
https://ncbi.nlm.nih.gov/pubmed/12350226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020657
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