Signal Transducer and Activator of Transcription 3 Is Required for Abnormal Proliferation and Survival of TSC2-Deficient Cells: Relevance to Pulmonary Lymphangioleiomyomatosis

Tumor suppressor complex TSC1/TSC2 represents a key negative regulator of mammalian target of rapamycin (mTOR)-S6 kinase 1 signaling. Mutational inactivation of TSC1 or TSC2, linked to a rare lung disease, lymphangioleiomyomatosis (LAM), manifests as neoplastic growth of smooth-muscle (SM)-like cell...

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Главные авторы: Goncharova, Elena A., Goncharov, Dmitry A., Damera, Gautam, Tliba, Omar, Amrani, Yassine, Panettieri, Reynold A., Krymskaya, Vera P.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769052/
https://ncbi.nlm.nih.gov/pubmed/19596836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.057042
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