Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027

The C-1027 enediyne antitumor antibiotic from Streptomyces globisporus possesses an (S)-3-chloro-5-hydroxy-β-tyrosine moiety, the chloro- and hydroxy- substituents of which are installed by a flavin-dependent halogenase SgcC3 and monooxygenase SgcC, respectively. Interestingly, a single flavin reduc...

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Hlavní autoři: Van Lanen, Steven G., Lin, Shuangjun, Horsman, Geoff P., Shen, Ben
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767520/
https://ncbi.nlm.nih.gov/pubmed/19817865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1574-6968.2009.01802.x
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