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Spiroborate Ester-Mediated Asymmetric Synthesis of β-Hydroxy Ethers and its Conversion to Highly Enantiopure β-Amino Ethers

[Image: see text] Borane-mediated reduction of aryl and alkyl ketones with α-aryl- and α-pyridyloxy groups affords β-hydroxy ethers in high enantiomeric purity (up to 99% ee) and in good yield, using as catalyst 10 mol % of spiroborate ester 1 derived from (S)-diphenylprolinol. Representative β-hydr...

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Bibliografiska uppgifter
Huvudupphovsmän: Huang, Kun, Ortiz-Marciales, Margarita, Correa, Wildeliz, Pomales, Edgardo, López, Xaira Y.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767257/
https://ncbi.nlm.nih.gov/pubmed/19413288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo900666r
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