Highly Enantioselective Borane Reduction of Heteroaryl and Heterocyclic Ketoxime Ethers Catalyzed by Novel Spiroborate Ester Derived from Diphenylvalinol: Application to the Synthesis of Nicotine Analogues

[Image: see text] An asymmetric synthesis for the preparation of nonracemic amines bearing heterocyclic and heteroaromatic rings is described. A variety of important enantiopure thionyl and arylalkyl primary amines were afforded by the borane-mediated enantioselective reduction of O-benzyl ketoximes...

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Main Authors: Huang, Kun, Merced, Francisco G., Ortiz-Marciales, Margarita, Meléndez, Héctor J., Correa, Wildeliz, De Jesús, Melvin
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701197/
https://ncbi.nlm.nih.gov/pubmed/18447392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo800204n
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