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Block of hERG K(+) Channel by Classic Histamine H(1) Receptor Antagonist Chlorpheniramine
Chlorpheniramine is a potent first-generation histamine H(1) receptor antagonist that can increase action potential duration and induce QT prolongation in several animal models. Since block of cardiac human ether-a-go-go-related gene (hERG) channels is one of leading causes of acquired long QT syndr...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Korean Physiological Society and The Korean Society of Pharmacology
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2766741/ https://ncbi.nlm.nih.gov/pubmed/19885040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2009.13.3.215 |
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