Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration

AIM: To investigate the effects of hydroxyzine on human ether-a-go-go-related gene (hERG) channels to determine the electrolphysiological basis for its proarrhythmic effects. METHODS: hERG channels were expressed in Xenopus oocytes and HEK293 cells, and the effects of hydroxyzine on the channels wer...

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Bibliographische Detailangaben
Hauptverfasser: Lee, Byung Hoon, Lee, Seung Ho, Chu, Daehyun, Hyun, Jin Won, Choe, Han, Choi, Bok Hee, Jo, Su-Hyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003299/
https://ncbi.nlm.nih.gov/pubmed/21892192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.66
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