Synthesis and Electrochemistry of 2-Ethenyl and 2-Ethanyl Derivatives of 5-Nitroimidazole and Antimicrobial Activity against Giardia lamblia

Infections with the diarrheagenic pathogen, Giardia lamblia, are commonly treated with the 5-nitroimidazole (5-NI) metronidazole (Mz), and yet treatment failures and Mz resistance occur. Using a panel of new 2-ethenyl and 2-ethanyl 5-NI derivatives, we found that compounds with a saturated bridge be...

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Detalhes bibliográficos
Main Authors: Valdez, Carlos A., Tripp, Jonathan C., Miyamoto, Yukiko, Kalisiak, Jaroslaw, Hruz, Petr, Andersen, Yolanda S., Brown, Sabrina E., Kangas, Karina, Arzu, Leo V., Davids, Barbara J., Gillin, Frances D., Upcroft, Jacqueline A., Upcroft, Peter, Fokin, Valery V., Smith, Diane K., Sharpless, K. Barry, Eckmann, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766634/
https://ncbi.nlm.nih.gov/pubmed/19480409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900356n
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