Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia

OBJECTIVES: The mechanism of action of, and resistance to, metronidazole in the anaerobic (or micro-aerotolerant) protozoan parasite Giardia lamblia has long been associated with the reduction of ferredoxin (Fd) by the enzyme pyruvate:ferredoxin oxidoreductase (PFOR) and the subsequent activation of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Leitsch, David, Burgess, Anita G., Dunn, Linda A., Krauer, Kenia G., Tan, Kevin, Duchêne, Michael, Upcroft, Peter, Eckmann, Lars, Upcroft, Jacqueline A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133484/
https://ncbi.nlm.nih.gov/pubmed/21602576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkr192
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados