Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia

OBJECTIVES: The mechanism of action of, and resistance to, metronidazole in the anaerobic (or micro-aerotolerant) protozoan parasite Giardia lamblia has long been associated with the reduction of ferredoxin (Fd) by the enzyme pyruvate:ferredoxin oxidoreductase (PFOR) and the subsequent activation of...

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Hlavní autoři: Leitsch, David, Burgess, Anita G., Dunn, Linda A., Krauer, Kenia G., Tan, Kevin, Duchêne, Michael, Upcroft, Peter, Eckmann, Lars, Upcroft, Jacqueline A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133484/
https://ncbi.nlm.nih.gov/pubmed/21602576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkr192
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