Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia

OBJECTIVES: The mechanism of action of, and resistance to, metronidazole in the anaerobic (or micro-aerotolerant) protozoan parasite Giardia lamblia has long been associated with the reduction of ferredoxin (Fd) by the enzyme pyruvate:ferredoxin oxidoreductase (PFOR) and the subsequent activation of...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Leitsch, David, Burgess, Anita G., Dunn, Linda A., Krauer, Kenia G., Tan, Kevin, Duchêne, Michael, Upcroft, Peter, Eckmann, Lars, Upcroft, Jacqueline A.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133484/
https://ncbi.nlm.nih.gov/pubmed/21602576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkr192
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars