Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity

Metronidazole and other 5-nitroimidazoles (5-NI) are among the most effective antimicrobials available against many important anaerobic pathogens, but evolving resistance is threatening their long-term clinical utility. The common 5-NIs were developed decades ago, yet little 5-NI drug development ha...

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Detalhes bibliográficos
Main Authors: Miyamoto, Yukiko, Kalisiak, Jarosław, Korthals, Keith, Lauwaet, Tineke, Cheung, Dae Young, Lozano, Ricardo, Cobo, Eduardo R., Upcroft, Peter, Upcroft, Jacqueline A., Berg, Douglas E., Gillin, Frances D., Fokin, Valery V., Sharpless, K. Barry, Eckmann, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808650/
https://ncbi.nlm.nih.gov/pubmed/24101497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302664110
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