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Synthesis and Electrochemistry of 2-Ethenyl and 2-Ethanyl Derivatives of 5-Nitroimidazole and Antimicrobial Activity against Giardia lamblia

Infections with the diarrheagenic pathogen, Giardia lamblia, are commonly treated with the 5-nitroimidazole (5-NI) metronidazole (Mz), and yet treatment failures and Mz resistance occur. Using a panel of new 2-ethenyl and 2-ethanyl 5-NI derivatives, we found that compounds with a saturated bridge be...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Valdez, Carlos A., Tripp, Jonathan C., Miyamoto, Yukiko, Kalisiak, Jaroslaw, Hruz, Petr, Andersen, Yolanda S., Brown, Sabrina E., Kangas, Karina, Arzu, Leo V., Davids, Barbara J., Gillin, Frances D., Upcroft, Jacqueline A., Upcroft, Peter, Fokin, Valery V., Smith, Diane K., Sharpless, K. Barry, Eckmann, Lars
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	2009
الموضوعات:	Article
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2766634/ https://ncbi.nlm.nih.gov/pubmed/19480409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900356n
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Synthesis and Electrochemistry of 2-Ethenyl and 2-Ethanyl Derivatives of 5-Nitroimidazole and Antimicrobial Activity against Giardia lamblia

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