Deficiency of type I IFN receptor in lupus-prone NZM 2328 mice decreases dendritic cell numbers and activation and protects from disease

Type I interferons are potent regulators of innate and adaptive immunity and are implicated in the pathogenesis of systemic lupus erythematosus. Here we report that clinical and pathological lupus nephritis and serum anti-nuclear antibody levels are greatly attenuated in NZM 2328 mice deficient in t...

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Detalhes bibliográficos
Main Authors: Agrawal, Hemant, Jacob, Noam, Carreras, Esther, Bajana, Sandra, Putterman, Chaim, Turner, Sean, Neas, Barbara, Mathian, Alexis, Koss, Michael N., Stohl, William, Kovats, Susan, Jacob, Chaim O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766036/
https://ncbi.nlm.nih.gov/pubmed/19812195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803872
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