Chronic NF-κB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response

Normal cells divide for a limited number of generations, after which they enter a state of irreversible growth arrest termed replicative senescence. While replicative senescence is due to telomere erosion, normal human fibroblasts can undergo stress-induced senescence in response to oncogene activat...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Batsi, Christina, Markopoulou, Soultana, Vartholomatos, George, Georgiou, Ioannis, Kanavaros, Panagiotis, Gorgoulis, Vassilis G., Marcu, Kenneth B., Kolettas, Evangelos
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765928/
https://ncbi.nlm.nih.gov/pubmed/19406145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2009.04.002
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi